Does Gene Variant Make Women More Prone To Alcoholism?

ScienceDaily (July 9, 2008) — A particular gene variant might make women more susceptible to alcoholism. At least, a study carried out by the Universities of Bonn and Sweden's Karolinska Institute makes this a plausible conclusion. Accord-ing to this, a gene in the endorphin metabolism is altered in a typical fashion more often in women alcoholics than in healthy women. In mice too, endorphins seem to play an important role in the amount of alcohol consumed, particularly among females.

Endorphins are known as 'happiness' hormones. They activate what is known as the reward system in the brain and thereby ensure a good mood. This could be the case after jogging (experts talk about 'Runner's High'), after a bar of chocolate or also after a glass of beer or wine. The body endeavours to repeat this high, in the worst case ending in addiction.

Without these 'happiness' hormones you should be going easy on the alcohol, the theory also says. Researchers have tested this hypothesis. For this they examined mice that could not produce any endorphins due to a genetic mutation. The laboratory mice had the choice of quenching their thirst with pure water or an ethanol solution. 'Overall, mice without endorphins drank less alcohol than their relatives with endorphins,' Dr. Ildikó Rácz from the Bonn Institute of Molecular Psychiatry explains. She led the study together with her colleague Britta Schürmann and the director of the institute, Professor Dr. Andreas Zimmer.

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