Wednesday, December 31, 2008

Open Letter to Dr. Donald Vereen

December 31, 2008

Dear Dr. DonaldVereen:

I am a psychologist with 30 years experience treating patients with drug and alcohol problems, founding member and twice past-president of the Addiction Division of New York State Psychological Association, trainer and author. See my background on my website, www.andrewtatarsky.com

It is my understanding that you are part of the team advising President-elect Obama on his selection of the next heads of ONDCP and SAMHSA. If that is not so I wonder if you would advise me who is.

Based on reports that Congressman Jim Ramstad is under consideration for heading ONDCP or SAMHSA, in conjuction with a large group of colleagues, I organized a sign-on letter to President-elect Obama expressing strong reservations about Rep. Jim Ramstad for either of these positions. The letter outlines these concerns and makes suggestions about what kind of leadership we believe would be suitable and what direction the next administration's drug policy should take. I am attaching the letter and a press release about it to this note.

At present we have over 430 mental health and substance use treatment professionals, researchers, academics and other concerned citizens signed on. You can see the list of signers at my website. Many are leaders in their fields who you know well.

I am aware that there are other groups, including Friends of NIDA, that have expressed their views on these matters. In many respects we are in agreement with their views but differ in some important ways.

So,I ask that you deliver this letter to President-elect Obama and consider our point of view in your selection process.

I would be very honored to have an opportunity to discuss these issues with you and others on the team. I could also organize a representative group of professionals who have signed the letter.

I look forward to you response and any thoughts about how we might support President-elect Obama in making the best choices for America for these critically important issues.

Sincerely,

Dr. Andrew Tatarsky

Tuesday, December 30, 2008

Drug War Chronicle Feature: Looking Forward -- Who Should Be the Next Drug Czar?

from Drug War Chronicle, Issue #560, 11/14/08

If there is one man who symbolizes and epitomizes the federal war on drugs, it is the head of the White House Office of National Drug Control Policy (ONDCP), colloquially known as the drug czar's office. For the last eight years, that man has been John Walters, a protege of conservative moralist Bill Bennett, the first ONDCP drug czar. With his anti-marijuana media campaigns, his innumerable press releases, and his interference in various state-level initiatives, Walters has been drug reform's bête noire.

Now, Walters and his boss, President Bush, are preparing to exit stage right, and the Obama administration will have to choose his successor. Given the foreign wars and failing economy facing the incoming administration, filling the drug czar position doesn't appear to be a high priority for the new resident at the White House. Only one name has been publicly mentioned, Los Angeles police chief William Bratton, and he has said he's not interested. A US News & World Report list of potential White House appointments doesn't even list any names for consideration as drug czar.

But for people interested in undoing some of the harms of the Bush era drug war, ONDCP is very important. As ONDCP explains on its home page:

"The principal purpose of ONDCP is to establish policies, priorities, and
objectives for the Nation's drug control program. The goals of the program are
to reduce illicit drug use, manufacturing, and trafficking, drug-related crime
and violence, and drug-related health consequences. To achieve these goals, the
Director of ONDCP is charged with producing the National Drug Control Strategy.
The Strategy directs the Nation's anti-drug efforts and establishes a program, a
budget, and guidelines for cooperation among Federal, State, and local
entities.


"By law, the director of ONDCP also evaluates, coordinates, and oversees
both the international and domestic anti-drug efforts of executive branch
agencies and ensures that such efforts sustain and complement State and local
anti-drug activities. The Director advises the President regarding changes in
the organization, management, budgeting, and personnel of Federal Agencies that
could affect the Nation's anti-drug efforts; and regarding Federal agency
compliance with their obligations under the Strategy."

So, who is it going to be? Drug reformers and others consulted this week by the Chronicle had few actual suggestions -- some worried that anyone suggested or supported by the reform movement would be doomed -- but plenty of ideas about what type of person should replace Walters. And some even speculated about the possibility of just doing away with the drug czar's office altogether.

"The reform community needs to be looking at someone who has a comprehensive public health orientation or who has an evidence-based focus," said Eric Sterling, former counsel to the House Judiciary Committee and currently president of the Criminal Justice Policy Foundation. "This would be someone who says goal number one is treatment of people with hard-core addiction problems and number two is to make sure our prevention programs are effective and well-grounded."

Sterling mentioned a couple of possibilities. "I don't think it's realistic to think we can get a reform sympathizer in there. It's not going to be Ethan Nadelmann. It needs to be someone who has administrative experience in some capacity. One possibility would be Chris Fichtner, the former head of mental health for the state of Illinois," Sterling suggested.

Fichtner is an associate professor of psychiatry at the University of Chicago who has worked with drug reformers in Illinois. He testified in favor of medical marijuana bills in Illinois and Wisconsin.

"Another possibility, someone I know the reform community had a lot of respect for before he went into government is Westley Clark, head of the federal Center for Substance Abuse Services," Sterling continued. "He's African-American, been at the federal level for a long time, has experience managing a federal agency, and a lot of experience in the field."

"If we had our druthers," said National Organization for the Reform of Marijuana Laws (NORML) executive director Allen St. Pierre, "it would be somebody like Ethan Nadelmann, with a comprehensive understanding of drugs, but that's a wet dream." Instead, he said, one name being kicked around was Mark Kleiman, a professor of Public Policy at the UCLA School of Public Affairs who has written extensively on drug policy and whose innovative ideas sometimes raise as many hackles in the reform community as they do among drug warriors.

Click here to continue reading article at Stop the Drug War.com

Friday, December 26, 2008

The Evidence Gap - Drug Rehabilitation or Revolving Door?

NYTimes.com
By BENEDICT CAREY
Published: December 22, 2008

ROSEBURG, Ore. — Their first love might be the rum or vodka or gin and juice that is going around the bonfire. Or maybe the smoke, the potent marijuana that grows in the misted hills here like moss on a wet stone.

But it hardly matters. Here as elsewhere in the country, some users start early, fall fast and in their reckless prime can swallow, snort, inject or smoke anything available, from crystal meth to prescription pills to heroin and ecstasy. And treatment, if they get it at all, can seem like a joke.

“After the first couple of times I went through, they basically told me that there was nothing they could do,” said Angella, a 17-year-old from the central Oregon city of Bend, who by freshman year in high school was drinking hard liquor every day, smoking pot and sampling a variety of harder drugs. “They were like, ‘Uh, I don’t think so.’ ”

She tried residential programs twice, living away from home for three months each time. In those, she learned how dangerous her habit was, how much pain it was causing others in her life. She worked on strengthening her relationship with her grandparents, with whom she lived. For two months or so afterward she stayed clean.

“Then I went right back,” Angella said in an interview. “After a while, you know, you just start missing your friends.”

Every year, state and federal governments spend more than $15 billion, and insurers at least $5 billion more, on substance-abuse treatment services for some four million people. That amount may soon increase sharply: last year, Congress passed the mental health parity law, which for the first time includes addiction treatment under a federal law requiring that insurers cover mental and physical ailments at equal levels.

Many clinics across the county have waiting lists, and researchers estimate that some 20 million Americans who could benefit from treatment do not get it.

Yet very few rehabilitation programs have the evidence to show that they are effective. The resort-and-spa private clinics generally do not allow outside researchers to verify their published success rates. The publicly supported programs spend their scarce resources on patient care, not costly studies.

And the field has no standard guidelines. Each program has its own philosophy; so, for that matter, do individual counselors. No one knows which approach is best for which patient, because these programs rarely if ever track clients closely after they graduate. Even Alcoholics Anonymous, the best known of all the substance-abuse programs, does not publish data on its participants’ success rate.

“What we have in this country is a washing-machine model of addiction treatment,” said A. Thomas McClellan, chief executive of the nonprofit Treatment Research Institute, based in Philadelphia. “You go to Shady Acres for 30 days, or to some clinic for 60 visits or 60 doses, whatever it is. And then you’re discharged and everyone’s crying and hugging and feeling proud — and you’re supposed to be cured.”

He added: “It doesn’t really matter if you’re a movie star going to some resort by the sea or a homeless person. The system doesn’t work well for what for many people is a chronic, recurring problem.”

In recent years state governments, which cover most of the bill for addiction services, have become increasingly concerned, and some, including Delaware, North Carolina, and Oregon, have sought ways to make the programs more accountable. The experience of Oregon, which has taken the most direct and aggressive action, illustrates both the promise and perils of trying to inject science into addiction treatment.

Evidence-Based Treatments

In 2003 the Oregon Legislature mandated that rehabilitation programs receiving state funds use evidence-based practices — techniques that have proved effective in studies. The law, phased in over several years, was aimed at improving services so that addicts like Angella would not be doomed to a lifetime of rehab, repeating the same kinds of counseling that had failed them in the past — or landing in worse trouble.

“You can get through a lot of programs just by faking it,” said Jennifer Hatton, 25, of Myrtle Creek, Ore., a longtime drinker and drug user who quit two years ago, but only after going to jail and facing the prospect of losing her children. “That’s what did it for me — my kids — and I wish it didn’t have to come to that.”

When practiced faithfully, evidence-based therapies give users their best chance to break a habit. Among the therapies are prescription drugs like naltrexone, for alcohol dependence, and buprenorphine, for addiction to narcotics, which studies find can help people kick their habits.

Click here to continue reading article at the New York Times

Drug Czar of My Dreams

The Huffington Post
Matt Elrod
Posted December 18, 2008 | 10:26 AM (EST)

For over 35 years America's war at home, the Drug War, has been raging. Owing in large part to drug war excesses, the United States now locks up more of its citizens than any nation on earth -- more than 2.3 million, with half a million of them behind bars for nonviolent drug offenses alone. That is more than Western Europe, with a much higher population, incarcerates for all crimes combined.

The historic election of Barack Obama signals a unique opportunity to begin to heal one of America's worst open sores and end the drug war, but that is not going to happen unless President-elect Obama nominates someone exceptional to the position of drug czar, or director of the White House Office of National Drug Control Policy. The appointment of "moderate" will not be sufficient, particularly when President-elect Obama's stated goals are to repeal the harshest drug sentences, remove federal bans on syringe-exchange funding to reduce HIV/AIDS, allow medical cannabis research, and support treatment alternatives for low-level drug offenders.

The Christian Science Monitor recently opined, "In his selection of a 'drug czar,' President-elect Obama needs to place more emphasis on addiction as a health problem," Christian Science Monitor, December 3, 2008. Columnist Maia Szalavitz, who covers addiction and treatment issues, perhaps put it best, "We need someone who knows the science, recognizes that there are many paths to recovery -- and understands that dead addicts can't recover," "Obama Drug Czar Pick: No Recovery from War on Drugs?", Huffington Post, November 21, 2008.

A significant reallocation of scarce resources from criminal justice to public health solutions is long overdue, but drug policy is multi-disciplinary and international in scope. We have had cops, doctors and soldiers. Call me crazy, but I think our drug czar should be an experienced drug policy expert who comprehends the full breadth, depth and importance of this issue on day one.

I have seen Reps. Dennis Kucinich and Ron Paul, and Judge Jim P. Gray suggested in comments appended to articles and blog posts on the topic, but I think Dr. Ethan Nadelmann, executive director of the Drug Policy Alliance, personifies the consummate drug policy expert, in both domestic and international affairs, that I would like to see directing the drug czar's office.

To this end, I started a petition called, "Drug Czar of My Dreams."

Perhaps Nadelmann for drug czar is too much to hope for but, with any luck, this petition will at least encourage President-elect Obama to think twice about his choice of drug czar. In addition to your signature and feedback, I would appreciate your help with promoting this petition.

Matthew M. Elrod

Monday, December 22, 2008

Press Release: Possible Obama Pick for “Drug Czar” or head of SAMHSA Criticized by Hundreds of Substance Abuse and Mental Health Treatment Professiona

For Immediate Release:
Contact: Andrew Tatarsky, PhD (212) 633-8157
Monday, December 22, 2008

Possible Obama Pick for “Drug Czar” or head of SAMHSA Criticized by Hundreds of Substance Abuse and Mental Health Treatment Professionals, Researchers and
Academics

Ramstad’s Positions on Syringe Exchange, Sentencing Reform, Medical Marijuana and other Issues Unscientific and Harmful Say Experts

Leading Substance Abuse and Mental Health Experts Suggest Six Positions that Leaders of ONDC and SAMHSA Should Support


A growing number of professionals have expressed concern about reports in the media that President-elect Obama may be considering appointing Republican Congressman Jim Ramstad (R-MN) either as the next “Drug Czar”, director of the Office of National Drug Control, or as director of SAMHSA, the Substance Abuse and Mental Health Services Administration. In a letter to President-elect Obama released today, over 250 clinicians working with patients with substance use problems and nearly 150 researchers, academics and other concerned citizens warn that Ramstad is not the man for either of these jobs because his record suggests that his perspective is ideologically based and at odds with science.

The letter applauds Rep. Ramstad’s support for expanding access to drug treatment and improving addiction awareness and it honors his own personal triumph over addiction. However, in spite of these contributions, Ramstad has supported unscientific faith-based treatment while opposing evidence-based practices such as methadone maintenance and syringe exchange, two of the most effective interventions for addiction and transmission of infectious disease that save lives. He has also consistently opposed congressional efforts to stop the arrest of patients with HIV/AIDS, cancer and other illnesses who use prescribed medical marijuana in states where it is legal and he has failed to co-sponsor legislation that would eliminate sentencing disparity between crack cocaine and powder cocaine, despite the fact that there were three different crack/powder reform bills in the 110th Congress. These positions clearly conflict with President-elect Obama’s stated positions on these issues.

These professionals call for President-elect Obama to select leaders for these critically important positions who are committed to reducing the harms associated with both drugs and punitive drug laws and who will base their decisions on science rather than politics or ideology.

They call for leaders who will support evidence-based treatment across the spectrum including:
  1. Non-abstinence based interventions like Motivational Interviewing, opiate substitution treatment and abstinence oriented treatment for appropriately matched patients
  2. Integrated treatment for patients with co-occurring disorders
  3. Syringe exchange programs to halt the spread of HIV and hepatitis-C

They also call for leaders who will treat substance abuse and dependence as health issues rather than as criminal issues and be committed to:
  1. Sentencing reform

  2. Better educating criminal justice professionals associated with drug courts in the complexities of substance use problems and their treatment and

  3. More fully involving clinical staff in decisions about individuals mandated by drug courts to treatment

The letter concludes, “There are many roads to recovery and recovery can take different paths…these views are in the best interests of individuals struggling with substance use disorders and all Americans”.

Click here for a copy of the letter and a complete list of signatories

New York Times
The Tierney Lab: Putting Ideas in Science to the Test
Drug Czar Controversy

December 8, 2008, 12:23 pm


— Updated: 12:23 pm --
By John Tierney

Some researchers in substance-abuse treatment and advocates for the medical use of marijuana are alarmed at reports that Representative Jim Ramstad, a Republican from Minnesota, is a candidate to become the next drug czar — the director of the office of National Drug Control Policy. In a joint letter to President-elect Barack Obama, coordinated by Andrew Tatarsky, the past president of the division of addictions of the New York State Psychological Association, dozens of academics and other professionals in substance-abuse treatment write:

This country needs a drug czar who supports evidence-based policies and one who will make decisions based on science, not politics or ideology. We strongly believe that Congressman Ramstad is not that person.

Rep. Ramstad voted in 1998 in favor of making permanent the federal funding ban on syringe exchange. In 2000, he voted to prohibit the District of Columbia from spending its own locally-raised funds on syringe exchange programs, and in 2007, he voted against lifting the same DC ban, despite decades of research showing that syringe exchange programs reduce the spread of HIV/AIDS, save lives, save money, and do not increase drug use. Representative Ramstad has also c onsistently opposed congressional efforts to stop the arrest of patients with HIV/AIDS, cancer, and other illnesses who use medical marijuana to ease their pain and suffering in states where it is legal.

Similar concerns have been raised in another joint letter, coordinated by the Drug Policy Alliance endorsed by more than three dozen other public-health, criminal-justice and drug-treatment organizations. They write to Mr. Obama:

You showed strong leadership on the campaign trail by pledging to lift the federal funding ban on syringe exchange programs, end the excessive federal law enforcement raids aimed at medical marijuana patients, and eliminate the crack/powder cocaine sentencing disparity. . .

We urge you to nominate for drug czar someone with a public health background, who is committed to reducing the spread of HIV/AIDS, hepatitis C and other infectious diseases, open to systematic drug policy reform, and able to show strong leadership on the issues you believe in.

The costs of the war on drugs are summed up by Ethan Nadelmann, the executive director of the Drug Policy Alliance, in a Wall Street Journal op-ed article celebrating the 75th anniversary of the repeal of Prohibition. After noting that that the repeal was popular not just among drinkers but also non-drinkers worried about the rise in organized crime and other consequences of Prohibition, Mr. Nadelmann writes:

They saw what most Americans still fail to see today: That a failed drug prohibition can cause greater harm than the drug it was intended to banish.

Consider the consequences of drug prohibition today: 500,000 people incarcerated in U.S. prisons and jails for nonviolent drug-law violations; 1.8 million drug arrests last year; tens of billions of taxpayer dollars expended annually to fund a drug war that 76% of Americans say has failed; millions now marked for life as former drug felons; many thousands dying each year from drug overdoses that have more to do with prohibitionist policies than the drugs themselv es, and tens of thousands more needlessly infected with AIDS and Hepatitis C because those same policies undermine and block responsible public-health policies.

And look abroad. At Afghanistan, where a third or more of the national economy is both beneficiary and victim of the failed global drug prohibition regime. At Mexico, which makes Chicago under Al Capone look like a day in the park. And elsewhere in Latin America, where prohibition-related crime, violence and corruption undermine civil authority and public safety, and mindless drug eradication campaigns wreak environmental havoc.

The joint letter to Mr. Obama organized by Dr. Tatarsky suggests a different approach: "We need a new bottom line for U.S. drug policy so that treatment is more available and addiction is treated like a health issue, not a criminal issue. To paraphrase former Baltimore Mayor Kurt Schmoke, we need a surgeon general, not a military general or police officer."

What do you think of Mr. Ramstad as drug czar? Do you have any other nominees for the job? Or other advice for Mr. Obama on drug policy?

Tuesday, December 16, 2008

Regarding the Selection of Directors of the Office of National Drug Control (the Drug Czar) and the Substance Abuse and Mental Health Services Agency


It was reported that Representative Ramstad has been lobbying to head up SAMHSA, the Substance Abuse and Mental Health Services Administration, with greater support from mental health and substance abuse professionals. The concerns that led to our sign on letter opposing Rep. Ramstad's possible selection as the next Drug Czar are even more applicable to his selection to head SAMHSA where he could do even more damage to the treatment of people with substance use disorders. For this reason I sent a note to the more than 350 signers of the first letter asking if they would support an ammendment to the original letter to express our str ong concern about Rep. Ramstad being selected for either agency, ONDC or SAMHSA. The support was unanimous and the letter was ammended. The ammended letter is posted below and the first version of the letter remains up on this blog.

********************************************************

December 16 2008

Dear President-Elect Obama,

As substance use and mental health professionals treating patients with substance use disorders, we are concerned about reports that you may be considering Congressman James Ramstad as our next “Drug Czar”, the director of the Office of National Drug Control Policy, or as director of the Substance Abuse and Mental Health Services Administration (SAMHSA) . This country needs leadership in these agencies that supports evidence-based policies and that will make decisions based on science, not politics or ideology. We have reason to believe that Congressman Ramstad is not that person.

While we applaud Representative Ramstad for his courageous and steady support for expanding drug treatment access and improving addiction awareness, and honor his own personal and very public triumph over addiction, we have strong reservations about his candidacy for these positions.

In his twenty-eight years in the U.S. House, Rep. Ramstad has consistently opposed policies that seek to reduce drug-related harm and create common ground on polarizing issues. Rep. Ramstad voted in 1998 in favor of making permanent the federal funding ban on syringe exchange,, in 2000, he voted to prohibit the District of Columbia from spending its own locally raised funds on syringe exchange programs, and in 2007, he voted against lifting the same DC ban, despite decades of research showing that syringe exchange programs reduce the spread of HIV/AIDS, save lives, save money, and do not increase drug use. Rep. Ramstad has also consistently opposed congressional efforts to stop the arrest of patients with HIV/AIDS, cancer, and other illnesses who use prescribed medical marijuana to ease their pain and suffering in states where it is legal.

Unlike you and Vice-President-Elect Biden, Rep. Ramstad has also failed to cosponsor any legislation eliminating the sentencing disparity between crack cocaine and powder cocaine, despite the fact that there were three different crack/powder reform bills in the 110th Congress. A number of recent studies have found that long prison sentences are one factor driving disproportionate rates of HIV/AIDS infections in communities of color. A primary task of the next Drug Czar should be to deal with this and other issues related to over-incarceration.

We need leadership that is committed to reducing the harms associated with both drugs and punitive drug laws. Leaders who support:

  1. Treatment interventions across the spectrum of readiness to change such as: Recovery Readiness, Motivational Interviewing, and other interventions which do not require abstinence for active substance users just beginning to work on their substance use; substitution treatments like methadone and buprenorphine (the most proven effective treatments for opiate dependent patients); and abstinence-focused in- and out-patient treatments for those working toward abstinence and recovery

  2. Integrated treatment for patients with co-occurring psychiatric, medical, and lifestyle problems – a group that makes up the majority of patients with serious substance use disorders

  3. Syringe exchange programs to halt the spread of HIV/AIDS and hepatitis C,. This is an intervention that has been proven to dramatically reduce the transmission of infectious disease and reduce drug use in the injecting population without increasing drug use

We need a new bottom line for U.S. drug policy so that treatment is more available and substance abuse and dependence are treated as the health issues they are, not criminal issues. To paraphrase former Baltimore Mayor Kurt Schmoke, we need a surgeon general not a military general or police officer.

We need leaders at ONDC and SAMHSA who welcome and encourage new ideas and research and who are committed to reducing the number of nonviolent offenders behind bars. These leaders should be fully committed to major sentencing reform. There should also be greater emphasis on educating our judges, prosecutors, and parole and probation officers to the complexities of substance use disorders and the process of change and recovery. When patients in treatment for substance use disorders "slip" it is more the norm than not; as an expected part of the process of change, it should not lead to automatic termination of treatment and incarceration. These decisions need to be made in conjunction with the clinical staff working with these patients who have the expertise to make them.

Our leadership on drug policy and treatment must understand that there are many roads to recovery and recovery can take different paths. We strongly believe that our views are in the best interests of individuals struggling with substance use disorders and all Americans and we hope they will be considered in your choices for these critically important positions.

Thank you.

Sincerely,

Andrew Tatarsky, PhD
Founding Executive Board Member and Past President, Division on Addictions, New York State Psychological Association

Debra Rothschild, PhD
Past President, Executive Committee, Division on Addictions, New York State Psychological Association

Howard Josepher, LCSW
President & Chief Executive Officer, Exponents

Alexandra Woods, PhD
Officer, Executive Committee, Division on Addictions, New York State Psychological Association

Julie Barnes, PhD
Executive Board Member, Division on Addiction, New York State Psychological Association

Click here to view the additional signatures to this letter

Thursday, December 11, 2008

Not Drug Czar -- Ramstad Now Wants to Head Treatment Agency. Just Say No!

Maia Szalavitz
Posted December 11, 2008 12:46 PM (EST)
The Huffington Post

Our coverage of the possible nomination of Rep. Jim Ramstad as "drug czar" has kicked up quite a fuss, spurring many comments here and a sign-on letter by addiction professionals that was cited by John Tierney in this week's New York Times. Nearly 300 leaders in the addiction treatment field so far have added their signatures. Now, the Minnesota Independent is reporting that Ramstad's real ambition is to serve as the head of the Substance Abuse and Mental Health Services Administration (SAMHSA).

While that sounds better than having him in charge of drug policy overall as "drug czar," in fact, it is a position in which he could possibly do more damage by replacing evidence-based treatment with ideology "behind the scenes."

Let's look once at his record. With politicians, I find that support for needle exchange tends to be a good proxy for whether you "follow the data" or follow the political winds of ideology. As we know, Ramstad went with ideology -- and even when he had a recent chance to revise his position to allow Washington, DC to use its own money for such programs, he remained firmly stuck in the past and voted to try to block that.

Then, there's methadone and other maintenance treatments. Against the weight of an Institute of Medicine study -- the Institute of Medicine is the agency charged by Congress with resolving medical controversies with data -- he opposed maintenance so much that he didn't want to give insurance parity for coverage.

In other words, while parity would have advanced all other addiction treatments, if his early parity bills had passed, the best-supported treatment for heroin addiction would have become harder to get.

Is someone who opposes what the science says is the best treatment for heroin addiction really someone we want in charge of the agency which is supposed to help disseminate evidence-based care?

And, of course, there's his earmark and other support for Teen Challenge. This is a "treatment provider" which claims that addiction is a sin, not a disease -- and the only help it offers for addicts is conversion to a particular form of Christianity. No medication, no evidence-based therapies, no credentialed counselors -- it doesn't even advise participation in 12-step programs, which is the one treatment modality we know Ramstad favors!

Ramstad sponsored a bill to change the name of the National Institute on Drug Abuse to the National Institute on Diseases of Addiction. As I wrote yesterday, either he really doesn't believe addiction is a disease -- in which case, he's a hypocrite and not someone we want running a treatment agency or he doesn't vet programs that he supports, in which case he's also not a good choice to head an agency that funds various kinds of treatment and initiatives [pdf] for promoting the best care.

The head of SAMSHA should be someone who promotes evidence-based treatment -- not someone who only supports the science when it bolsters his personal beliefs.

[And, so that I don't have to write this piece ever again, Ramstad should not be considered as head of the National Institute on Drug Abuse -- the agency in charge of research on addictions at NIH, no matter what name it turns out to be given -- either!]

Critics Attack Ramstad as Possible Drug Czar Candidate

Join Together.org
December 10, 2008

Former Rep. Jim Ramstad (R-Minn.) might not even be in the running for the job of Barack Obama's drug czar, but that hasn't stopped critics from saying he would be a poor choice because of his past opposition to needle-exchange programs and medical marijuana.

Ramstad's name has been floated as a possible pick for director of the Office of National Drug Control Policy (ONDCP) in the Obama administration, although some sources say he is more likely to be tapped as head of the Substance Abuse and Mental Health Services Administration (SAMHSA).

Letter-writing campaigns by the Drug Policy Alliance (DPA), a group of addiction-treatment professionals led by the past president of the addictions division at the New York State Psychological Association, and the National Black Police Association (NBPA) urge the president-elect not to make Ramstad the nominal chief of the national war on drugs.

"While we applaud Representative Ramstad for his courageous and steady support for expanding drug treatment access and improving addiction awareness, and honor his own personal and very public triumph over addiction, we have strong reservations about his candidacy for the drug czar position," according to the letter sent to Obama and signed by DPF and NBPA as well as a variety of AIDS prevention groups and others. "In his twenty-eight years in the U.S. House, Representative Ramstad has consistently opposed policies that seek to reduce drug-related harm and create common ground on polarizing issues."

Writing in the Huffington Post, Maia Szalavitz also criticized Ramstad for once earmarking $235,000 for the Minnesota chapter of the controversial Teen Challenge program.

Obama's transition team has not made any public announcements about filling the position of ONDCP director.

Monday, December 8, 2008

Drug Czar Controversy - Tierney Lab @ NY Times mentions Andrew Tatarsky's sign-on letter

December 8, 2008, 12:23 pm
By John Tierney
NY Times

Some researchers in substance-abuse treatment and advocates for the medical use of marijuana marijuana are alarmed at reports that Representative Jim Ramstad, a Republican from Minnesota, is a candidate to become the next drug czar — the director of the office of National Drug Control Policy. In a joint letter to President-elect Barack Obama, coordinated by Andrew Tatarsky, the past president of the division of addictions of the New York State Psychological Association, dozens of academics and other professionals in substance-abuse treatment write:
This country needs a drug czar who supports evidence-based policies and one
who will make decisions based on science, not politics or ideology. We strongly
believe that Congressman Ramstad is not that person.

Rep. Ramstad voted in 1998 in favor of making permanent the federal funding
ban on syringe exchange. In 2000, he voted to prohibit the District of Columbia
from spending its own locally-raised funds on syringe exchange programs, and in
2007, he voted against lifting the same DC ban, despite decades of research
showing that syringe exchange programs reduce the spread of HIV/AIDS, save
lives, save money, and do not increase drug use. Representative Ramstad has also
consistently opposed congressional efforts to stop the arrest of patients with
HIV/AIDS, cancer, and other illnesses who use medical marijuana to ease their
pain and suffering in states where it is legal.

Similar concerns have been raised in another joint letter, coordinated by the Drug Policy Alliance endorsed by more than three dozen other public-health, criminal-justice and drug-treatment organizations. They write to Mr. Obama:

You showed strong leadership on the campaign trail by pledging to lift the federal funding ban on syringe exchange programs, end the excessive federal law enforcement raids aimed at medical marijuana patients, and eliminate the crack/powder cocaine sentencing disparity. . . We urge you to nominate for drug czar someone with a public health background, who is committed to reducing the spread of HIV/AIDS, hepatitis C and other infectious diseases, open to systematic drug policy reform, and able to show strong leadership on the issues you believe in.

The costs of the war on drugs are summed up by Ethan Nadelmann, the executive director of the Drug Policy Alliance, in a Wall Street Journal op-ed article celebrating the 75th anniversary of the repeal of Prohibition. After noting that that the repeal was popular not just among drinkers but also non-drinkers worried about the rise in organized crime and other consequences of Prohibition, Mr. Nadelmann writes:

They saw what most Americans still fail to see today: That a failed drug prohibition can cause greater harm than the drug it was intended to banish.

Consider the consequences of drug prohibition today: 500,000 people incarcerated in U.S. prisons and jails for nonviolent drug-law violations; 1.8 million drug arrests last year; tens of billions of taxpayer dollars expended annually to fund a drug war that 76% of Americans say has failed; millions now marked for life as former drug felons; many thousands dying each year from drug overdoses that have more to do with prohibitionist policies than the drugs themselves, and tens of thousands more needlessly infected with AIDS and Hepatitis C because those same policies undermine and block responsible public-health policies.

And look abroad. At Afghanistan, where a third or more of the national economy is both beneficiary and victim of the failed global drug prohibition regime. At Mexico, which makes Chicago under Al Capone look like a day in the park. And elsewhere in Latin America, where prohibition-related crime, violence and corruption undermine civil authority and public safety, and mindless drug eradication campaigns wreak environmental havoc.

The joint letter to Mr. Obama organized by Dr. Tatarsky suggests a different approach: “We need a new bottom line for U.S. drug policy so that treatment is more available and addiction is treated like a health issue, not a criminal issue. To paraphrase former Baltimore Mayor Kurt Schmoke, we need a surgeon general, not a military general or police officer.”

What do you think of Mr. Ramstad as drug czar? Do you have any other nominees for the job? Or other advice for Mr. Obama on drug policy?

Saturday, December 6, 2008

Letter to President Elect Obama Regarding the Selection of our Next Drug Czar…From Substance Use and Mental Health Treatment Professionals


Click here to sign-on to the letter at Andrew Tatarsky's website.

Dear President-Elect Obama,

As substance-use and mental-health professionals treating patients with substance use disorders, we are concerned about reports that President-elect Obama is considering Congressman James Ramstad as our next “Drug Czar,” or director of the Office of National Drug Control Policy. This country needs a Drug Czar who supports evidence-based policies and one who will make decisions based on science, not politics or ideology. We strongly believe that Congressman Ramstad is not that person.

While we applaud Representative Ramstad for his courageous and steady support for expanding drug treatment access and improving addiction awareness, and honor his own personal and very public triumph over addiction, we have strong reservations about his candidacy for the Drug Czar position. In his twenty-eight years in the U.S. House, Rep. Ramstad has consistently opposed policies that seek to reduce drug-related harm and create common ground on polarizing issues.

Rep. Ramstad voted in 1998 in favor of making permanent the federal funding ban on syringe exchange. In 2000, he voted to prohibit the District of Columbia from spending its own locally-raised funds on syringe exchange programs, and in 2007, he voted against lifting the same DC ban, despite decades of research showing that syringe exchange programs reduce the spread of HIV/AIDS, save lives, save money, and do not increase drug use. Rep. Ramstad has also consistently opposed congressional efforts to stop the arrest of patients with HIV/AIDS, cancer, and other illnesses who use medical marijuana to ease their pain and suffering in states where it is legal.

Unlike you and Vice-President-Elect Biden, Rep. Ramstad has also failed to cosponsor any legislation eliminating the sentencing disparity between crack cocaine and powder cocaine, despite the fact that there were three different crack/powder reform bills in the 110th Congress. A number of recent studies have found that long prison sentences are one factor driving disproportionate rates of HIV/AIDS infections in communities of color. A primary task of the next Drug Czar should be to deal with this and other issues related to over-incarceration.

We need someone committed to reducing the harms associated with both drugs and punitive drug laws. Someone who supports:

1. Treatment interventions across the spectrum of readiness to change such as: Recovery Readiness, Motivational Interviewing, and other interventions which do not require abstinence for active substance users just beginning to work on their substance use; substitution treatments like methadone and buprenorphine (the most proven effective treatments for opiate-dependent patients); and abstinence-focused in- and out-patient treatments for those working toward abstinence and recovery.

2. Integrated treatment for patients with co-occuring psychiatric, medical, and lifestyle disorders – a group that makes up the majority of patients with serious substance use disorders.

3. Syringe exchange programs to halt the spread of HIV/AIDS and hepatitis C,. This is an intervention that has been proven to dramatically reduce the transmission of infectious disease and reduce drug use in the injecting population without increasing drug use.

We need a new bottom line for U.S. drug policy so that treatment is more available and addiction is treated like a health issue, not a criminal issue. To paraphrase former Baltimore Mayor Kurt Schmoke, we need a surgeon general not a military general or police officer.

We need a Drug Czar who welcomes and encourages new ideas and research. We need a Drug Czar who is committed to reducing the number of nonviolent offenders behind bars. Our country's next Drug Czar should be fully committed to major sentencing reform. There should also be greater emphasis on educating our judges, prosecutors, and parole and probation officers to the complexities of substance use disorders and the process of change and recovery. When patients in treatment for substance use disorders "slip" it is more the norm than not; as an expected part of the process of change, it should not lead to automatic termination of treatment and incarceration. These decisions need to be made in conjunction with the clinical staff working with these patients who have the expertise to make them.

We need a Drug Czar who understands there are many roads to recovery and recovery can take different paths. We strongly believe that our views are in the best interests of individuals struggling with substance use disorders and all Americans and will be considered in your choice of the next Drug Czar.

Thank you.

Sincerely,
Andrew Tatarsky, PhD
Founding Executive Board Member and Past President, Division on Addictions, New York State Psychological Association

Click to view signatures already on the letter

Thursday, December 4, 2008

APSAD Annual Scientific Conference 2008 - Australasian Professional Society on Alcohol and other Drugs.

November 23 - 26, 2008 Part I (Sunday 23 Nov).

This year's APSAD conference was a fine affair. I must have been to 15 or more of these in most State capitals, Cairns and Canberra. I missed last year’s Fest in Auckland but those who attended said it was excellent. Like national leaders’ meetings with their funny hats, shirts and coats, each APSAD conference is characterised by its own conference attaché bag. This natural-inspired over-the-shoulder model was one of the few I could imagine using in the future.

The venue was splendid, Darling Harbour being just an 8 minutes (downhill) walk from Town Hall station which made me into a commuter again. With medical practice responsibilities I was a part-time conference goer.=C 2 Thus these notes are incomplete and (as usual) opinionated.

The Sunday afternoon pre-conference session had been booked by the only drug company with a major stake in our field. Reckitt-Benckiser is manufacturer of buprenorphine which is the only registered alternative to methadone, the latter being a generic drug with small bread-and-butter profit lines in comparison. The sponsors began with the topics of pharmaceutical abuse and innovations in addiction management, then ending with two presentations on the potential cardiac complications of methadone before a panel discussion to which I had been invited (and generously funded).

Adrian Dunlop spoke eloquently about the past, present and future of addiction treatments.

Dr Eric Strain covered some historical details of non-medical use of pharmaceuticals in the US, giving some results on prevalence and consequences from household surveys over 25 years. Apparently most users obtained their supplies from one doctor; many from friends or relatives with less only ~1% or less from the internet. Australian figures may be quite different as people are entitled to attend more than one doctor on Medicare. Another speaker quipped that if Australia had a Bill of Rights, it would include being able to attend “as many doctors as you like”. Dr Strain touched on the gap between occasional use and dependent use, something some of us may still forget because of the selected referrals we receive. The other major differences between American street heroin users and those abusing pain killers is that the latter are more likely to be employed, white race and non-injectors. Dr Strain was too modest to mention his own research on buprenorphine abuse and perhaps too polite to mention the reported non-medical use of buprenorphine, including a naloxone combination product which became the drug of choice (mostly injected) by more than half those presenting for treatment in Wellington, New Zealand (see Robinson 1993).

Dr Nick Lintzeris gave some pointers about pharmaceutical abuse in Australia. His talk ending with a plea to put methadone treatment, including side effects, into context both globally, as well as for individual patients. In his rather frequent exposure during the conference, he reminded us that there are much more relevant issues for opioid therapy as patients get older such as testosterone levels, calcium leaching, osteoporosis, dental, viral and bowel problems.

Jason White detailed the rather sparse literature on cardiac complications in methadone recipients. He seemed persuaded that the connection between methadone and torsade is significant and that methadone treatment could be restricted or further regulated as a result. As a demonstration of patients on ‘normal’ methadone treatment coming to torsade, he cited Pearson and Woosley’s report of 59 FDA notifications from 1969 to 2002. While not fully documented, from the limited data 12 could have been on ‘standard’ MMT, 8 of whom were over 40 years of age. This leaves just 4 reported ‘standard’ MMT cases in the USA over a 33 year period in the age group we normally start on MMT. Justo’s more recent literature review found only 6 of 40 cases reported could have been on ‘standard’ MMT cases without other triggering factors (85% had one or more of these known causes of QT prolongation aside from high methadone doses).
0A
QT prolongation on the cardiograph has long been know to occur in about a quarter of methadone patients yet its only serious consequence, ‘torsade de pointes’ tachycardia, hardly ever seems to occur in young patients (<40>40 years of age, electrolyte disturbance,20etc.

As our patient population on maintenance treatment gets older so we must be more vigilant about this and other eventualities. As with other related medical issues, close attention should be paid to cardiac status. This may include an ECG in those taking over 150mg, those prescribed other ‘at risk’ medications or those with HIV or personal/family history of unexplained syncope or fainting.

At this session I was delighted to finally learn the origin of the term ‘ether-a-go-go’ which is from the rhythmic dancing induced in the legs of doomed drosophila drones (flies) under the influence of ether in genetic experiments on channel blockers.

We were then shown a 15 minute video ‘interview’ with Colorado cardiologist Dr Mori Krantz detailing blow by blow the now supposedly conclusive case for methadone’s guilt beyond reasonable doubt in causing fatal arrhythmias. The final proof of any medical argument, we are told, involves randomisation of subjects and so the RCT by Wedam is proffered. This trial, a secondary analysis of ECG tracings obtained incidentally in a 1990s RCT, showed very high rates of QT prolongation in the first 4 months of MMT but no cases of torsade. On e of the panellists said to me privately that this appears to be rather persuasive of the safety of methadone rather than the opposite.

As above, hardly anyone has ever seen a case except in patients who are already stressed and in highly complex medical circumstances. I note that since his classic description of 17 non-fatal cases in 2002 (8 were pain management cases), Krantz has only reported two other individual cases of torsade, one of which was due to cocaine.

In the video, we are told that because one cannot diagnose an electrical disturbance after death, coroners are unable to detect whether the death was due to cardiac arrhythmia or respiratory depression from the drug. In fact many cases are very clear at autopsy as having the classic findings of post mortem sub-acute lung changes and high blood levels as to leave little doubt abou t the cause of death. So while Krantz’s proposition may be true for a certain minority, with a 20% mortality, there ought to be 4 times as many (80%) torsade survivors. Yet few if any of these ever seem to get to an emergency room (or ambulance) and have their potentially fatal problem diagnosed with a simple cardiograph tracing. Such reports are exceedingly scarce or non-existent. I called one of Australia’s busiest casualty departments to be told that their long-time medical director had never seen a case of methadone associated torsade. He also pointed out that for the past several years, modern cardiograph machines have given an automated print-out of QTc, making this information much more available that previously. This just might be the single most important cause of the ‘epidemic’ of electrical changes in the absence of actual symptomatic disease.

Further on in the presentation Krantz states the obvious it’s not to say that there is an epidemic of cardiac events in America”. Yet elsewhere he has written that large number of patients are at risk of developing torsade. Fanoe’s Copenhagen syncope study was put up as a written question in the video ‘interview’ (there was no interviewer as such) but Krantz failed to comment on it for some reason. Fanoe showed that out of 800 cases (with no torsade reported) that high rates of syncope (over 20% in most dose groups) in methadone patients was at least in part substantially explained by cardiac conduction problems such as torsade. This is hard to understand for a complication known to occur in less than 1% of patients). Krantz then alluded to Chugh’s Portland study suggesting that it lent support to his torsade theory, yet like so many of the other quoted references, this is another report which does not document any torsade cases. Perhaps I belabour the point. Where are all the bodies in this serial killing, Miss Marple?

[more about lives saved in another conference posting shortly]

Comments by Andrew Byrne ..

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Dr Andrew Byrne MB BS (Syd) FAChAM (RACP)
Dependency Medicine,
75 Redfern Street, Redfern,
New South Wales, 2016, Australia
Email - ajbyrne@ozemail.com.au
Tel (61 - 2) 9319 5524 Fax 9318 0631
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Surgery web page: http://www.redfernclinic.com/#news


References:

Robinson GM, Dukes PD, Robinson BJ, Cooke RR, Mahoney GN. The misuse of buprenorphine and a buprenorphine-naloxone combination in Wellington, New Zealand. Drug Alcohol Dependence 1993 33;1:81-6

Strain EC, Stoller K, Walsh SL, Bigelow GE. Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers. Psychopharmacology (Berl) 2000 Mar;148(4):374-83

Justo D. Methadone-Induced Long QT Syndrome vs Methadone-Induced Torsades de Pointes. Arch Intern Med 2006 166:2288

Wedam EF, Bigelow GE, Johnson RE, Nuzzo PA, Haigney MCP. QT-Interval Effects of Methadone, Levomethadyl, and Buprenorphine in a Randomized Trial. Arch Intern Med 2007 167;22:2469-2473

Krantz MJ, Lewkowiez L, Hays H, Woodroffe MA, D. Robertson AD, Mehler PS. Torsade de Pointes Associated with Very-High-Dose Methadone. Ann Intern Med. 2002 137:501-504

Krantz MJ, Rowan SB, Mehler PS. Cocaine-related torsade de pointes in a methadone maintenance patient. J Addict Dis. 2005;24(1):53-60

Krantz MJ, Garcia JA, Mehler PS. Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes. Pharmacotherapy 2005 25:611-614

Fanoe S, Hvidt C, Ege P, Jensen GB. Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen. Heart 2007;93;1051-1055

Chugh SS, Socoteanu C, Reinier K, Waltz J, Jui J, Gunson K. A Community-Based Evaluation of Sudden Death Associated with Therapeutic Levels of Methadone. American Journal of Medicine 2008 121: 66-71

Thursday, October 30, 2008

Can Sips at Home Prevent Binges?

By ERIC ASIMOV
Published: March 26, 2008
New York Times

PARENTS always want to share their passions with their children. Whether you’re a fan of baseball or the blues, sailing or tinkering with old cars, few things are as rewarding as seeing a spark of receptivity in the eyes of the next generation.

It usually doesn’t take. Most of the time kids — teenagers, anyway — would as soon snicker at their old man’s obsessions as indulge him. Even so, I can’t help hoping that my sons might share my taste in music and food, books and movies, ball teams and politics. Why should wine be any different?

It’s the alcohol, of course, which makes wine not just tricky but potentially hazardous. Nonetheless, I would like to teach my sons — 16 and 17 — that wine is a wonderful part of a meal. I want to teach them to enjoy it while also drumming it into them that when abused, wine, like any other alcoholic beverage, can be a grave danger.

As they were growing up I occasionally gave them tastes from my glass — an unusual wine, perhaps, or a taste of Champagne on New Year’s Eve. They’ve had sips at Seders and they see wine nightly at our dinner table. With both boys now in high school, I thought it was time to offer them the option of small tastes at dinner.

In European wine regions, a new parent might dip a finger in the local pride and wipe it lovingly across an infant’s lips — “just to give the taste.” A child at the family table might have a spoonful of wine added to the water, because it says, “You are one of us.” A teenager might have a small glass of wine, introducing an adult pleasure in a safe and supervised manner. This is how I imagined it in my house.

But about a year ago, my wife attended a gathering on the Upper East Side sponsored by several high schools addressing the topic of teenagers and alcohol.

The highly charged discussion centered on the real dangers of binge drinking and peer pressure, of brain damage and parental over-permissiveness, and of the law.

One authority disparaged the European model, saying that teenage drinking in Europe —never mind which part — is much worse than it is in the United States. The underlying message was that nothing good comes from mixing alcohol and teenagers.

My wife was shaken. We agreed to hold off on the tasting plan. But I decided to try to get some answers myself.

Click here to continue reading article at New York Times

Tuesday, October 21, 2008

Drug Offers Effective Alternative Treatment for Heroin Addicts

October 20, 2008
Research Summary

The latest research from the North American Opiate Medication Initiative (NAOMI) suggests that hydromorphone -- an opiate found in prescription cough medicines like Dilaudid -- is more effective than methadone in reducing rates of illicit drug use and improving abstinence retention rates among opiate addicts, the National Post reported Oct. 18.

NAOMI researchers prescribed medical-grade heroin, methadone and hydromorphone to individuals addicted to heroin. After three years, the study found that those both the heroin-maintenance and hydromorphone group had better outcomes than the methadone group. Hydromorphone was so effective that almost all the participants in the group believed they were being given heroin.

"To be perfectly frank, there is a stigma attached to heroin. That would make [hydromorphone] particularly attractive in places where the concept of using heroin would be untenable as a public policy," said Martin Schechter, lead investigator of the project and director of the University of British Columbia School of Population and Public Health.

Schechter said that while there would be challenges to using hydromorphone to treat addiction, the hurdles would be small compared to getting prescription heroin approved. The researchers are already in negotiations with the Vancouver Coastal Health Authority about making the NAOMI research center into a permanent drug-treatment clinic that would offer methadone and hydromorphone maintenance.

From Join Together.org - Research News

Wednesday, October 15, 2008

Drinking Alcohol Associated With Smaller Brain Volume

ScienceDaily (Oct. 14, 2008)

The more alcohol an individual drinks, the smaller his or her total brain volume, according to a new report.

Brain volume decreases with age at an estimated rate of 1.9 percent per decade, accompanied by an increase in white matter lesions, according to background information in the article. Lower brain volumes and larger white matter lesions also occur with the progression of dementia and problems with thinking, learning and memory. Moderate alcohol consumption has been associated with a lower risk of cardiovascular disease; because the brain receives blood from this system, researchers have hypothesized that small amounts of alcohol may also attenuate age-related declines in brain volume.

Carol Ann Paul, M.S., of Wellesley College, Mass., and colleagues studied 1,839 adults (average age 60) who were part of the Framingham Offspring Study, which began in 1971 and includes children of the original Framingham Heart Study participants and their spouses. Between 1999 and 2001, participants underwent magnetic resonance imaging (MRI) and a health examination. They reported the number of alcoholic drinks they consumed per week, along with their age, sex, education, height, body mass index and Framingham Stroke Risk Profile (which calculates stroke risk based on age, sex, blood pressure and other factors).

"Most participants reported low alcohol consumption, and men were more likely than women to be moderate or heavy drinkers," the authors write. "There was a significant negative linear relationship between alcohol consumption and total cerebral brain volume."

Although men were more likely to drink alcohol, the association between drinking and brain volume was stronger in women, they note. This could be due to biological factors, including women's smaller size and greater susceptibility to alcohol's effects.

"The public health effect of this study gives a clear message about the possible dangers of drinking alcohol," the authors write. "Prospective longitudinal studies are needed to confirm these results as well as to determine whether there are any functional consequences associated with increasing alcohol consumption. This study suggests that, unlike the associations with cardiovascular disease, alcohol consumption does not have any protective effect on brain volume."

This study was supported by a contract from the National Heart, Lung, and Blood Institute's Framingham Heart Study, National Institutes of Health; grants from the National Institute on Aging; and a grant from the National Institute of Neurological Disorders and Stroke.

Monday, October 13, 2008

Thinner Cortex In Cocaine Addicts May Reflect Drug Use And A Pre-existing Disposition To Drug Abuse

ScienceDaily (Oct. 13, 2008)

New research findings suggest that structural abnormalities in the brains of cocaine addicts are related in part to drug use and in part to a predisposition toward addiction. The research, published by Cell Press in the October 9th issue of the journal Neuron, maps the topography of the addicted brain and provides new insight into the effect of cocaine on neural systems mediating cognition and motivation.

"Human studies have shown differences in how addicts make judgments and decisions, but it is not well understood how these differences relate to alterations in the structure of the brains of addicts. Claims have been made that cocaine, potentially in connection with alcohol or other drugs, may be toxic to brain cells. We sought evidence supporting a hypothesis that brain thickness is reduced in some brain regions in addicts, is related to altered decision-making and cognition, and might to some limited degree, be connected to their exposure to cocaine," explains senior study author Dr. Hans Breiter from Massachusetts General Hospital.

Dr. Breiter and colleagues found that brain regions involved with regulation of attention and reward, specifically the dorsolateral prefrontal cortex (DLPFC) and insular cortices, were significantly thinner in cocaine addicts when compared with matched controls. Behavioral tests revealed that the thinner cortex was associated with restrictions in preference-based judgment and decision-making, and with less accurate effortful attention. A general reduction in the level of preference and in the range of decisions reflecting these preferences can be considered an example of a fundamental feature of addiction—the loss of interest in many things outside of drug use.

Some cortical thickness differences were associated with years of drug use, but the researchers also observed differences in the symmetry of DLPFC thickness between control subjects and cocaine addicts that suggested predisposition to drug abuse. "In human and animal studies, differences in the structure of the right and left sides of the brain are important for many behaviors, and when these normal differences in brain structure are altered, there may be a genetic basis for the change. We found an altered right/left relationship in a part of the frontal cortex that was also associated with altered judgment and decision-making in addicts. We further found that the overall brain thickness in the cocaine addicts was more uniform across the brain, which is quite different from what is observed in non-drug users. These differences did not correlate with any drug use measure. Together, this set of findings point to predisposing factors being a potential contributing factor to the addiction," explains Dr. Breiter.

In total, these observations provide evidence that cortical thickness abnormalities associated with cocaine addiction may be a reflection of both drug use and a preexisting inclination to drug abuse. "A fundamental component of addiction may involve adaptations and/or developmental predispositions involving brain regions necessary for judgment and decision-making regarding complex rewards and attention towards goal-objects. Addiction thus may represent a complex phenotype with multiple effects necessary for compulsive drug use, and the resulting restriction in the range of behaviors they show," concludes Dr. Breiter.

Saturday, October 11, 2008

Sacred Intentions - Inside The Johns Hopkins Psilocybin Studies



"And I felt like I was being whisked...whoa, boy...and then I went to all these other places." [Sandy Lundahl (left)]; "We have to move beyond the concept of getting high and seek to become more mature human beings. " [Bill Richards]


By Michael M. Hughes

Sandy Lundahl lies on a couch, her eyes covered with a dark cloth mask. She's listening to classical music through enormous headphones: Brahms' Symphony No. 2, the "Kyrie" from Bach's Mass in B Minor, Barber's Adagio for Strings. An hour earlier, she had swallowed two blue capsules containing close to 30 milligrams of psilocybin, the primary active chemical in Psilocybe cubensis and other "magic" mushrooms, and she's already well on her way on a trip into the hidden spaces of her psyche.

Lundahl, a 55-year-old self-described skeptic and health educator from Bowie, is looking for God.

Two experienced guides are with her in the room, monitoring her: Mary Cosimano, a clinical social worker, and William "Bill" Richards, a white-haired, 68-year-old psychiatrist and scholar of comparative religion. He's sitting cross-legged on the carpet in front of the couch, ready to help Lundahl--to talk her out of any negative trips, to help her remain focused on the scenes unfolding behind the mask, to offer a drink or some fruit or escort her to the bathroom. The space resembles a clean, warm, but decidedly offbeat living room. The lighting is spare and soft, emanating from two lamps. A bookshelf holds a variety of picture books and well-known spiritual and psychological classics like Freud's The Interpretation of Dreams and The Varieties of Religious Experience by William James. Above the books sits a wooden sculpture of Psilocybe mushrooms. Behind the couch are a Mesoamerican mushroom stone replica and a statue of a serene, seated Buddha. An eye-popping abstract expressionist painting hangs on the wall, an explosion of color and intersecting lines.

This isn't a metaphysical retreat center in San Francisco, or the Manhattan office of a New Age therapist-cum-shaman. Lundahl's first psychedelic experience is taking place in the heart of the Behavioral Biology Research Center building at the Johns Hopkins Bayview campus in Southeast Baltimore, in a room affectionately referred to by both the scientists and the volunteers as the "psilocybin room." She's taking part in the first study of its kind since the early '70s--a rigorous, scientific attempt to determine if drugs like psilocybin and LSD, demonized and driven underground for more than three decades, can facilitate life-changing, transformative mystical experiences.

The study, which took place from 2001 to 2005, and was published in 2006 in the journal Psychopharmacology with a follow-up in 2008 in the Journal of Psychopharmacology, made news around the globe and was greeted by nearly unanimous praise by both the scientific community and the mainstream press. Flying in the face of both government policy and conventional wisdom, its conclusion--that psychedelic drugs offer the potential for profound, transformative, and long-lasting positive changes in properly prepared individuals--may herald a revival in the study of altered states of consciousness.

Nonetheless, Lundahl, for one, wasn't initially impressed by the vibrant imagery behind her closed eyelids.

Click here to continue reading article and see more images at the Baltimore City Paper

Friday, October 10, 2008

Law Equalizes Coverage For Mental, Physical Care

'Milestone' Measure Could Expand Treatment Services

By Chris L. Jenkins
Washington Post Staff Writer
Friday, October 10, 2008; Page B01

An estimated 113 million Americans, including hundreds of thousands in the Washington region, will receive better insurance coverage for their mental health and substance abuse problems because of landmark legislation that for the first time requires mental and physical illnesses to be treated equally.

The law is a culmination of a decade of lobbying and negotiating among advocates for the mentally ill, the insurance industry, the business community -- including the U.S. Chamber of Commerce -- and doctors' groups. The change, which was included in the economic rescue package signed by President Bush last week, will take effect Jan. 1, 2010, for most plans. Businesses with 50 or fewer employees would be exempt.

For decades, insurance companies could offer less coverage for the treatment of depression, anxiety and bipolar disorder than of such diseases as cancer and diabetes -- so people with mental illness or substance abuse problems often had to pay for expensive treatment and medication out-of-pocket.

The new law bars companies from setting higher co-pays or deductibles for mental health and substance abuse treatment. Plans also will be prohibited from lowering benefit levels or restricting the number of outpatient therapy sessions or hospital treatment days. And if a health plan allows out-of-network visits for the treatment of physical illnesses, it will also have to offer identical out-of-network coverage for mental health care.

Advocates and experts said the change represents a fundamental shift in how the mentally ill are treated and could bring medical parity to tens of millions of people.

"This is absolutely milestone legislation for those people who have mental health and substance abuse problems," said Doug Walter, counsel for legislative and regulatory affairs at the American Psychological Association. "It ends the discrimination against people who have long needed the help."

Click here to continue reading article at The Washington Post

Monday, October 6, 2008

Psychoanalytic Therapy Wins Backing

By BENEDICT CAREY
Published: September 30, 2008

Intensive psychoanalytic therapy, the “talking cure” rooted in the ideas of Freud, has all but disappeared in the age of drug treatments and managed care.

But now researchers are reporting that the therapy can be effective against some chronic mental problems, including anxiety and borderline personality disorder.

In a review of 23 studies of such treatment involving 1,053 patients, the researchers concluded that the therapy, given as often as three times a week, in many cases for more than a year, relieved symptoms of those problems significantly more than did some shorter-term therapies.

The authors, writing in Wednesday’s issue of The Journal of the American Medical Association, strongly urged scientists to undertake more testing of psychodynamic therapy, as it is known, before it is lost altogether as a historical curiosity.

The review is the first such evaluation of psychoanalysis to appear in a major medical journal, and the studies on which the new paper was based are not widely known among doctors.

The field has resisted scientific scrutiny for years, arguing that the process of treatment is highly individualized and so does not easily lend itself to such study. It is based on Freud’s idea that symptoms are rooted in underlying, often longstanding psychological conflicts that can be discovered in part through close examination of the patient-therapist relationship.

Experts cautioned that the evidence cited in the new research was still too meager to claim clear superiority for psychoanalytic therapy over different treatments, like cognitive behavior therapy, a shorter-term approach. The studies that the authors reviewed are simply not strong enough, these experts said.

Click here to continue reading article at the New York Times

Sunday, October 5, 2008

Adolescent Insomnia Linked To Depression And Substance Abuse During Adolescence And Young Adulthood

ScienceDaily (Oct. 5, 2008)

A study in the Oct. 1 issue of the journal Sleep shows that adolescent insomnia symptoms are associated with depression, suicide ideation and attempts, and the use of alcohol, cannabis and other drugs such as cocaine.

Findings suggest that the presence of insomnia in adolescents increases the risk of developing mental health problems and also may increase the severity of these problems. Results indicate that adolescents who had symptoms of insomnia were 2.3 times more likely to develop depression in early adulthood than adolescents without symptoms of insomnia. Specifically, at baseline, the insomnia group was more likely to use alcohol, cannabis, and non-cannabis drugs, and was more likely to suffer from depression, suicide thoughts, and suicide attempts. The insomnia group also had a greater risk of developing new incidences of depression and suicide attempts after excluding participants who suffered from these specific psychopathologies at baseline.

When excluding participants who endorsed any mental health problem at baseline, the insomnia group was significantly more likely to develop incident depression. In addition, gender differences emerged for alcohol use, cannabis use, non-cannabis drug use, and depression. Independently of insomnia status, males were significantly more likely to endorse alcohol use, cannabis use, and the use of other drugs, while females were twice as likely to develop depression.

"Previous research in adults has found similar results to this study," said principal investigator and lead author Brandy M. Roane, MS, a doctoral student at the University of North Texas. "The current study suggests adolescents with insomnia are more prone to developing mental disorders, specifically depression."

Insomnia symptoms were reported by 9.4 percent of the adolescents in the study. Information discovered during this study could potentially provide parents, educators and mentors with a sign of a risk factor for the development of mental health issues.

The study involved 4,494 adolescents between 12 and 18 years of age at the beginning of the study, and 3,582 young adults between the ages of 18 and 25 years in a six-to-seven year follow up. One-hundred and forty-five U.S. middle, junior and high schools were selected to participate based on size, school type, census region, level of urbanization, percentage of Caucasian and African-American students, grade span and curriculum. Health-related variables such as height, weight, pubertal development, mental health status, and chronic and disabling conditions were obtained through in-home interviews and self-report.

Adolescents who reported having trouble falling asleep every day or almost every day were categorized as having insomnia symptoms. Binge drinking was defined as drinking five or more alcoholic beverages in a row, and suicide ideation was based on whether or not a participant had endorsed having thoughts of suicide in the last year.

Thursday, October 2, 2008

Strict Societies May Foster Violent Drinking Cultures

ScienceDaily (Oct. 2, 2008)

Countries with strict social rules and behavioral etiquette such as the United Kingdom may foster drinking cultures characterized by unruly or bad behavior, according to a new report on alcohol and violence released today by International Center for Alcohol Policies (ICAP). The report lists 11 cultural features that may predict levels of violence such as homicide and spousal abuse.

The report, “Alcohol and Violence: Exploring Patterns and Responses,” examines the association between alcohol and violence through the disciplines of anthropology, clinical psychology, human rights law, gender, and public health.

“We need to look more closely at the meaning attached to both drinking and violence in different cultures, without assuming that the one causes the other,” writes Anne Fox, PhD, a contributor to the report and founding director of Galahad SMS Ltd. in England.

Dr. Fox writes that the presence of certain cultural features can largely predict levels of homicide, spousal abuse and other forms of violence. Violence-reinforcing cultures tend to share the following features:

* Cultural support (in media, norms, icons, myths, and so on) for aggression and aggressive solutions;
* Militaristic readiness and participation in wars—societies that are frequently at war have consistently higher rates of interpersonal violence as well;
* Glorification of fighters;
* Violent sports;
* Corporal and capital punishment;
* Socialization of male children toward aggression;
* Belief in malevolent magic;
* Conspicuous inequality in wealth;
* A higher than normal proportion of young males in the society;
* Strong codes of male honor—in general, societies and subgroups that actively subscribe to strong codes of honor tend to have higher rates of homicide;
* A culture of male domination.

In her paper, “Sociocultural Factors that Foster or Inhibit Alcohol-related Violence,” Dr. Fox argues that efforts to counteract a “culture of violence” and “the male propensity for aggression” should be channeled toward altering “beliefs about alcohol” and “social responses to violence and aggression.”

The report includes other papers including “The Role of Drinking Patterns and Acute Intoxication in Violent Interpersonal Behaviors” which looks at patterns of violence at the individual level. The paper “Working with Culture to Prevent Violence and Reckless Drinking” studies alcohol and violence from a gender perspective and identifies strategies used to respond to analogous social problems. “Practical Responses: Communications Guidelines for First Responders in Cases of Alcohol-related Violence” presents international guidelines for enhanced communication among first responders (police, emergency room staff, social workers) to alcohol-related violence, particularly between the health and law enforcement sectors.

Monday, September 29, 2008

Pregnant and Addicted to Heroin

Expectant Mother Is One of Many Addicts in America's Heartland

By LISA LING and KATIE HINMAN
RICHLAND COUNTY, Ohio, Sept. 29, 2008

Merry Doerr has spent her whole life in the American farmbelt, a rural pocket of green tucked into the middle of Ohio. She's close to her family, living with her mother and 4-year-old daughter.

With her blond hair and blue eyes, Doerr embodies the classic American look -- and says she grew up with classic American values.

"When I grew up, my mom had raised me in Christian beliefs," she said, "and I knew ... right from wrong based on the Bible. I was a cheerleader. I had a lot of friends."

But life is different now. Doerr, who is five months pregnant and preparing for her second child, is not like other young mothers. She's a heroin addict.

"I wake up at 4 o'clock in the morning, dope sick with my stomach in cramps and sweating," she said, describing the symptoms of heroin withdrawal. "I have to get up out of bed at 4 o'clock in the morning, and go and use. And then I go back to bed and I wake up a few hours later and have to go use again."

Doerr said she uses heroin to keep that pain at bay.

"This is what I need to be normal," Doerr said. "You know I have to do dope every day to be normal. If I didn't have my dope this morning, I would be laying in bed right now thrashing around and vomiting. I wouldn't be able to function. I need [heroin] to function every day."

'Snowing Heroin' in Rural Ohio

It turns out that in the rural heartland of Ohio, halfway between the big cities of Cleveland and Columbus, heroin is everywhere.

"I would say it's up to epidemic proportions as far as the heroin," said Dane Howard of the Huron County Sheriff's Office. "Everywhere you go, it's like it's snowing heroin."

People here say heroin is indeed blanketing the main streets of tiny towns such as Plymouth, Ohio, where Doerr grew up. Doerr's mother, Patti Case, a schoolteacher, said so many people in their town of 1,800 were addicted to heroin that she moved her family, hoping to distance her daughter from the problem. But they found that the problem stretched across the region.

"There's probably not a family here, not just Plymouth but the surrounding area, that hasn't been touched by heroin," said Charlie Doan, chief of the Plymouth Police Department. "I think a lot of that started with Oxycontin."

In the mid-1990s, OxyContin, the highly addictive prescription pain killer, was being widely abused in rural communities like this one.

"About a decade ago, OxyContin got a strong foothold here in this whole region" said Howard. "The dealers drove the price up."

Click here to continue reading article at ABC News Health

Sunday, September 28, 2008

A Message from Dr. Andrew Tatarsky

Dear Friends,

I am putting together a piece on empirical support for harm reduction psychotherapy for my website. www.andrewtatarsky.com I have thought for years that we need one spot where people can go to find the evidence supporting this approach and this will be a beginning for me.

There is much indirect support for harm reduction psychotherapy from 50 years of research on therapeutic alliance, goal choice, motivational interventions, etc. I wonder if you are aware of any studies that have looked specifically at harm reduction psychotherapy that you can let me know of, send copies of or point me to. I am also interested in gathering the work on indirect support and would love to know what you are aware of in this area as well.

I will keep you posted on my results and I appreciate any and all thoughts on this subject.

Best,
Andrew Tatarsky, PhD

House vs. House: Vicodin Addiction and Hearing Loss

Hearing Expert Dr. John House Calls Out Dr. Gregory House on Vicodin Addiction

ESSAY by JOHN HOUSE, M.D.
Sept. 20, 2008

"Are you the famous Dr. House on television?"

During my career as a physician, there has been confusion regarding which Dr. House I am. I was confident that they were referring to my father, Dr. Howard House, the founder of the House Ear Institute, or my uncle, Dr. William House, who created and implanted the first FDA-approved cochlear implant.

But now I have discovered that there is another popular "Dr. House," TV's Dr. Gregory House on Fox's "House, M.D."

The show's popularity is not to be denied, but I have a very real concern about a message and theme that runs through each episode. It is not his poor bedside manner. It is not his mistreatment of residents. It is his addiction to Vicodin (acetaminophen/ hydrocodone) that is the problem.

Here at the House Clinic, my colleagues and I have seen a significant number of patients who have become addicted to Vicodin and have gone completely deaf. They have been taking 15 to 75 tablets per day and in a short period of time have developed a rapidly progressive hearing loss, which leads to permanent total deafness.

New research released this week by the Kaiser Family Foundation indicates that people are receiving important health information from prime-time television shows. Although the study looked at the storyline of another medical drama and not "House, M.D.," the important finding is that 45.6 percent of the audience surveyed remembered the key medical information six weeks later.

Click here to continue reading article at ABC News

Accuracy, Efficacy And Ethics Of Abstinence-only Programs Questioned By Public Health Experts

ScienceDaily (Sep. 19, 2008) — Studies published in a special issue of the online journal Sexuality Research and Social Policy by the University of California Press reveal that abstinence-only-until-marriage sex education programs fail to change sexual behavior in teenagers, provide inaccurate information about condoms, and violate human rights principles.

Edited by John S. Santelli, MD, MPH, professor and chair of the Heilbrunn Department of Family and Population Health and Leslie M. Kantor, MPH, assistant professor of clinical Population and Family Health at the Columbia University Mailman School of Public Health, the theme issue examines scientific and ethical implications of federal abstinence-only policies and programs.

In sum, the articles show that abstinence-only programs contain medical inaccuracies, fail to help young people to change behavior, and conflict with ethical standards. Abstinence-only programs violate young people's right to accurate information—and also teachers' and health educators' rights to answer questions and provide medically accurate information. Many states have now refused to participate in the federal program (25 states as of August 2008) citing concerns about efficacy and accuracy of abstinence-only programs. The federal program provides funding for abstinence-only education and restricts information about contraception and other aspects of human sexuality.

"Abstinence-only programs have a broad variety of problems with accuracy, efficacy, and ethics," Dr. Santelli. "These studies clearly demonstrate that federal promotion of abstinence has failed in its primary goal of helping young people delay initiation of sex, and actually, withholds life-saving information from young people."

Click here to continue reading article at Science Daily

Potential New Drug For Cocaine Addiction And Overdose

ScienceDaily (Sep. 16, 2008) — Chemists are reporting development of what they term the most powerful substance ever discovered for eliminating cocaine from the body, an advance that could lead to the world's first effective medicine for fighting overdoses and addictions of the illicit drug.

Their findings are scheduled for the Sept. 24 issue of the Journal of the American Chemical Society, a weekly publication.

In the new study, Chang-Guo Zhan and colleagues point out no effective anti-cocaine medication currently exists for cocaine abuse. One of the most promising approaches focuses on substances that mimic butyrylcholinesterase (BChE), a natural blood protein that helps break down and inactivate the drug, researchers say. However, natural BChE is too weak and ineffective for medical use, the researchers note.

The researchers describe design and produce the most potent, stable BChE structure ever produced. In lab studies, that form of BChE broke down, or metabolized, cocaine 2,000 times faster than the body's natural version of BChE, the scientists say, noting that reducing levels of the drug in the blood is a key to fighting overdose in humans. The substance also prevented convulsions and death when injected into mice that were given overdoses of cocaine, they note.

Tuesday, September 23, 2008

In Tangle of Young Lips, a Sex Rebellion in Chile

Below is part of a NY Tizmes article addressing sexual behavoir among teenagers in Chile. Harm Reduction would be valuable and necessary in this case, where the abstinence-only approach has clearly been tossed out, and the kids are going do what they will.

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By ALEXEI BARRIONUEVO
Published: September 12, 2008

SANTIAGO, Chile — It is just after 5 p.m. in what was once one of Latin America’s most sexually conservative countries, and the youth of Chile are bumping and grinding to a reggaetón beat. At the Bar Urbano disco, boys and girls ages 14 to 18 are stripping off their shirts, revealing bras, tattoos and nipple rings.

The place is a tangle of lips and tongues and hands, all groping and exploring. About 800 teenagers sway and bounce to lyrics imploring them to “Poncea! Poncea!”: make out with as many people as they can.

And make out they do — with stranger after stranger, vying for the honor of being known as the “ponceo,” the one who pairs up the most.

Chile, long considered to have among the most traditional social mores in South America, is crashing headlong into that reputation with its precocious teenagers. Chile’s youths are living in a period of sexual exploration that, academics and government officials say, is like nothing the country has witnessed before.

“Chile’s youth are clearly having sex earlier and testing the borderlines with their sexual conduct,” said Dr. Ramiro Molina, director of the University of Chile’s Center for Adolescent Reproductive Medicine and Development.

The sexual awakening is happening through a booming industry for 18-and-under parties, an explosion of Internet connectivity and through Web sites like Fotolog, where young people trade suggestive photos of each other and organize weekend parties, some of which have drawn more than 4,500 teenagers. The online networks have emboldened teenagers to express themselves in ways that were never customary in Chile’s conservative society.

Click here to continue reading the article at the New York Times

Friday, September 12, 2008

Hurdles Keep Street Drugs Out of Medicine Chest

From Marijuana to Ecstasy, Scientists Fight to Study Illicit Drugs' Medical Properties

By RUSSELL GOLDMAN
Sept. 11, 2008

The patients at Dr. Michael Mithoefer's clinic in South Carolina all suffer from post-traumatic stress disorder. Some are the victims of rape and child sexual abuse, others -- veterans returning home from Iraq -- bear the psychic scars of war.

They have tried other therapies before but here, under the watchful eye of Mithoefer and his staff, they're trying something new -- MDMA, better known as ecstasy, a drug that if bought on a street corner would land these patients in jail.

The results of the Mithoefer study -- the first Food and Drug Administration-approved Phase 2 trial of MDMA to treat post-traumatic stress -- will not be known until it concludes later this month. But the treatment already shows promise, the doctor says.

"We have had some very dramatic results," Mithoefer said. "We have examples of people on disability for years who have now returned to work. The treatment has had a profound effect on a number of people whose symptoms are now much better. It hasn't been that way for everybody but, overall, this seems to be much more effective than what is currently out there."

Like an ex-con trying to clean up his act and leave behind his criminal past, illicit drugs have a hard time shaking off their bad reputations. Many illegal drugs such as MDMA and marijuana could have pharmacological futures. Others such morphine and cocaine were initially developed for medicinal purposes, and some can be found in your medicine cabinet masquerading under assumed names. But scientists looking to do new research say it is difficult to get funding or approval for studies on drugs with rap sheets.

Click here to continue reading article at ABC Health News

Wednesday, September 10, 2008

Children of Alcoholics Forced Into Adulthood

Studies Show Children of Alcoholics Suffer Lifelong Effects but Can Bounce Back

By SUSAN DONALDSON JAMES
Sept. 10, 2008

"What is your emergency?" asked the 911 operator. The little boy replied, "My mom is making me blow air into her interlock."

The Albuquerque, N.M., youngster was asked to help his mother break the law and blow into her ignition interlock device to start the car. Police responded to the call this week and charged 30-year-old Genevieve Sullivan with violating her probation for drunken driving.

The 11-year-old walked a fine emotional line: He told operators he was afraid his mother would hear him and he'd get in trouble. But he was even more afraid of the consequences should his mother drive drunk.

Experts say children of alcoholics bear a heavy psychological burden for the sins of their parents. They are forced into adulthood early and spend much of their growing up years protecting themselves and their families.

"He knew at 11," said New York state psychologist Pat O'Gorman, who isn't involved with the New Mexico case. "He knew his mother was in trouble. He knew she needed help, and he knew he could provide that help."

According to the National Council on Alcoholism and Drug Dependence, nearly 14 million Americans are considered problem drinkers and 76 million are exposed to alcoholism in family settings.

Studies suggest about one in four children in the United States is exposed to alcohol abuse or dependence sometime before the age of 18, according to the Children of Alcoholics Foundation.

Click here to continue reading article at ABC Health News